Stem cells are the unspecialised cells that have the exceptional ability to renew themselves through cell division and under certain natural or experimental conditions; they can be induced to become specialised cell types. Generally, adult stem cells, embryonic stem cells, and induced stem cells are popular amongst various stem cells. Of these stem cells, no considerable ethical concern has been raised against the use of Adult Stem Cell; however, Embryonic Stem cell has been under the controversy from the very beginning. This is because embryonic stem cells are derived by destroying the embryo, which some scholars considered as equivalent to the human being. Thus, destroying an embryo is similar to the killing of a human being. Simultaneously, these stem cells have a therapeutic use, and some scholars also presume that treatment of diseases like Diabetes, Cancer, and hurt is possible through stem cells. To understand Stem Cell Research, this article discusses first in part I about stem cell research and types of stem cells. In part II, we will discuss the importance of stem cell research with some case studies and possibilities of the therapeutic use of stem cell for the COVID-19. In part III, we will analyse the ethical, moral, religious, and other issues against the use of stem cell research. In part IV, we will analyse the existing legal framework and patentability of stem cells in the UK, USA, and India. Finally, in part V, we will discuss findings and concludes. In this paper, the researcher has applied the doctrinal method of research based on the secondary data available on the various locations of the internet, books, and case laws.